2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105064B
    Zoniporide hydrochloride 241800-97-5 98%
    Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM).
    Zoniporide hydrochloride
  • HY-105167A
    E 047/1 128995-51-7 98%
    MW-436 (E 0471) hydrochloride is a benzofuran compound with antiarrhythmic effects. MW-436 hydrochloride can be used for the research of cardiovascular disease.
    E 047/1
  • HY-105226A
    CI-988 meglumin 130404-91-0 98%
    CI-988 meglumin is a cholecystokinin 2 receptor (CCK2R) antagonist. CI-988 meglumin prevents the gastrin-mediated protection of the heart with ischemia/reperfusion injury.
    CI-988 meglumin
  • HY-105269A
    Org 30029 hydrochloride 101041-95-6 98%
    Org 30029 hydrochloride is a Ca2+ sensitizer with positive inotropic effect. Org 30029 hydrochloride can be used for the research of cardiovascular disease.
    Org 30029 hydrochloride
  • HY-105408A
    Fandosentan potassium 221246-12-4 98%
    Fandosentan potassium is a potent endothelin A receptor (ETAR) antagonist. Fandosentan potassium inhibits CYP2C9 and CYP3A4 activities with IC50 values of 39.6 and 21.6 μM, respectively. Fandosentan potassium reverses the hypoxic pulmonary vasoconstriction in the perinatal lamb. Fandosentan potassium can be used for pulmonary hypertension research[1][2].
    Fandosentan potassium
  • HY-105439A
    Clofilium phosphate 68379-03-3 98%
    Clofilium phosphate (LY 150378) is an antiarrhythmic/antifibrillatory agent. Clofilium phosphate significantly prolongs the action potential duration and effective refractory period of canine cardiac Purkinje fibers, increases the ventricular fibrillation threshold, reduces the risk of reentrant arrhythmias, and enables spontaneous conversion of some ventricular fibrillation episodes to sinus rhythm. Clofilium phosphate is applicable to research related to ventricular fibrillation, arrhythmias, and ventricular tachyarrhythmias.
    Clofilium phosphate
  • HY-105449A
    KB R6933 148565-09-7 98%
    KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952). KB R6933 can inhibit 5-HT-induced bradycardia.
    KB R6933
  • HY-105627A
    Profadol hydrochloride 2324-94-9 98%
    Profadol (CI-572) hydrochloride is a potent analgesic agent. Profadol is a µ-opioid receptor (MOR) agonist. Profadol hydrochloride activates the γ-aminobutyric acid (GABA) receptors and inhibits the N-methyl-D-aspartate (NMDA) receptor. Profadol increases the mRNA and protein expression of MOR.
    Profadol hydrochloride
  • HY-105628A
    Prodilidine hydrochloride 3734-16-5 98%
    Prodilidine (CI-427) hydrochloride is a potent analgetic agent.
    Prodilidine hydrochloride
  • HY-105646A
    Chromonar hydrochloride 655-35-6 98%
    Chromonar hydrochloride (Carbocromen hydrochloride) is an orally active, selective long-acting coronary vasodilator. Chromonar hydrochloride increases coronary blood flow. Chromonar hydrochloride is used for the research of angina pectoris.
    Chromonar hydrochloride
  • HY-10564S1
    Sarpogrelate-d4 hydrochloride 98%
    Sarpogrelate-d4 (MCI-9042-d4) hydrochloride is deuterium labeled Sarpogrelate (hydrochloride). Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis.
    Sarpogrelate-d4 hydrochloride
  • HY-105651A
    Butalamine hydrochloride 56974-46-0 98%
    Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle.
    Butalamine hydrochloride
  • HY-106024A
    Alagebrium bromide 181069-80-7 98%
    Alagebrium bromide is an analog of Alagebrium Chloride (HY-106024B), a glucose cross-link blocker. Alagebrium Chloride disrupts glucose cross-links and may improve ventricular and arterial compliance. Alagebrium Chloride improves left ventricular diastolic filling and has the potential to inhibit diastolic heart failure (DHF).
    Alagebrium bromide
  • HY-106045A
    Imazodan hydrochloride 89198-09-4 98%
    Imazodan hydrochloride is the hydrochloride form of Imazodan (HY-106045). Imazodan hydrochloride is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan hydrochloride serves also as a peripheral vasodilator.
    Imazodan hydrochloride
  • HY-106111A
    Nafagrel hydrochloride 97901-22-9 98%
    Nafagrel hydrochloride is a thromboxane A2 synthetase inhibitor. Nafagrel hydrochloride can prevent the accumulation of thrombus material in a rat model of acute arterial thrombosis.
    Nafagrel hydrochloride
  • HY-106150A
    Eniporide mesylate 190368-98-0 98%
    Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content.
    Eniporide mesylate
  • HY-106162A
    ONO-1714 214479-33-1 98%
    ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis.
    ONO-1714
  • HY-106200A
    CJ-13,610 hydrochloride 179420-27-0 98%
    CJ-13,610 (hydrochloride) is an orally active and potent nonredox-type 5-lipoxygenase inhibitor with an IC50 value of 0.07 μM. CJ-13,610 (hydrochloride) competes with activating LOOH at a regulatory LOOH-binding site with high affinity, thereby preventing 5-lipoxygenase catalysis. CJ-13,610 (hydrochloride) is promising for research of diseases related to elevated levels of 5-lipoxygenase such as inflammatory reactions, allergic asthma, various types of cancer and atherosclerosis.
    CJ-13,610 hydrochloride
  • HY-106324A
    Sergolexole maleate 108674-87-9 98%
    Sergolexole maleate is a potent 5-HT2 receptor antagonist. Sergolexole maleate antagonizes serotonin-amplified platelet aggregation.
    Sergolexole maleate
  • HY-106330A
    Ipazilide fumarate 115436-74-3 98%
    Ipazilide fumarate (Win 54177-4 fumarate) is an antiarrhythmic agent. Ipazilide fumarate reduces K+- depolarized tone. Ipazilide fumarate prolongs ventricular refractoriness and possesses antiectopic activity.
    Ipazilide fumarate
Cat. No. Product Name / Synonyms Application Reactivity